Mechanisms allowing protein delivery in nasal mucosa using NPL nanoparticles

The Fungi Flora of Healthy Nasal Mucosa in Kerman, Iran

Introduction: Environmental fungi, molds and yeasts, can infest the nasal cavity through inhaled air. There is some evidence that they could be the main cause of Chronic Rhinosinusitis (CRS) but little is known about the normal fungal flora in the human nose. The objective of this study was to assess the normal fungal flora of the nasal mucus in adults in Kerman. Materials and Methods: We ...

Vaccine delivery using nanoparticles

Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive. In many cases the failure to devise vaccines is a consequence of the inability of vaccine candidates to evoke appropriate immune responses. This is especially true where cellular immunity is required for p...

Protein Delivery from Polymeric Nanoparticles

Aim of this work was to compare the efficacy of two loading methods of proteins onto polymeric nanocarriers: adsorption and encapsulation methods. Preliminary studies of protein loading were done using Bovine Serum Albumin (BSA) as model protein. Nanocarriers were prepared starting from polylactic co-glycolic acid (PLGA) polymer; production methods used are two different variants of emulsion ev...

Design and evaluate alginate nanoparticles as a protein delivery system

In recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. It is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. The aim of this study was to synthesis alginate nanoparticles ...

Uptake and Transport Pathways for Ultrafine Nanoparticles (Quantum Dots) in the Nasal Mucosa